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lecture 3 - DNA Replication an overview 1 Last Time DNA is...

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DNA Replication an overview 1
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Last Time DNA is the genetic material Components Forces holding strands together (3) Higher order structure 2
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DNA Replication an overview General features of DNA replication: DNA is replicated semi-conservatively The origin of replication is non-random Replication is bi-directional Mechanics of replication DNA polymerases synthesize DNA Leading and Lagging strands, initiated by a primer DNA ligases join strands 3
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Overview General features of DNA replication Basic mechanics of replication http://www.itg.uiuc.edu/technology/atlas/structures/nucleus_actin/images/nucleus_actin.jpg homepage.mac.com/enognog/cell%20cycle.jpg 4
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How is DNA replicated? 5
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Fig. 20.1 Three hypothetical models 1. 2. 3. 6
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Matthew Meselson Franklin Stahl Classic experiment to distinguish between 3 replication models 1958 “the most beautiful experiment in biology” 7
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Conservative H H H H L L Expected results H H HH LL shift Dispersive H H mixed mixed all mixed Expected results H H L H L H shift Figure 20.3 H L H H L H Semi- conservative Expected results H H L H H L L L L L L H second generation shift LL L H 8
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DNA replication is semi-conservative first generation H L H H L H Semi- conservative Expected results H H L H H L L L L L L H second generation shift LL L H 9
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Does DNA replication begin at the same site in every replication cycle?
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