BMS PowerPoint Revised

BMS PowerPoint Revised - AdoptiveCellTherapyfor...

Info iconThis preview shows pages 1–10. Sign up to view the full content.

View Full Document Right Arrow Icon
Adoptive Cell Therapy for  Metastatic Melanoma Cancer Team: Shauna Collins, Jordan Gales, and May Matsunami
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Melanoma is responsible for over 75% of skin cancer  deaths. Melanoma can metastasize and spread to other organs.  Only occurs in small percentage Dudley, et al, 2008. Rakel: Textbook of Family Medicine, 7th ed.
Background image of page 2
Why Adoptive Cell Therapy? Melanoma  is one of the most common types of cancer  among young adults. Most common among Caucasian males Dudley, et al, 2008.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Why Adoptive Cell Therapy? Adoptive cell therapy shows the most effective results  for treatment of melanoma, though these results are  not markedly successful as of yet 
Background image of page 4
What is adoptive cell therapy (ACT)? Where do the cells for ACT come from? Why is adoptive cell transfer considered the most  effective therapy for metastatic melanoma?
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Selected Terms and Definitions   Metastasis  (Metastatic Disease)- Spread  of a disease from one organ/body part to  another. Only malignant tumor cells and  infections are known to have the ability to  metastasize.  Cancer cells “leak” from a primary tumor  and travel through the lymphatic and blood  vessels, to settle down within normal tissue  elsewhere in the body. Tumors created this  was are referred to as secondary tumors. Fang L,Lonsdorf AS,Hwang ST,  Kumar: Robbins and Cotran 
Background image of page 6
Melanoma-   A Malignant tumor of the melanocytes. Melanocytes-   Cells located in the bottom of the epidermis, the middle layer of the eye, the inner  ear, meninges, the bowls, bones, and heart. Melanocytes are the cells that produce the pigment  melanin.    Melanoma commonly can occur in pigmented tissues such as the eye and intestine, as well as  the skin.   Melanoma is one of the rarer types of skin cancer but causes the majority of skin cancer deaths. 160,000 new cases diagnosed a year worldwide.  Estimated new cases and deaths  from  melanoma in the United States in 2008:    -New cases: 62,480     -Deaths: 8,420  Habif: Clinical Dermatology National Cancer Institute Definitions Continued… •Individuals with fair skin, many moles, family history of skin cancer, a weakened immune system, history of skin cancer, exposure to UV rays, and history of severe sunburns are at risk for skin cancer and melanoma .
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Melanocyte  Location-
Background image of page 8
Definitions Continued… Adoptive Cell Therapy-  T cell based Immunotherapy T Cells-  Belong to a group of white blood cells (lymphocytes) that play a central role in cell  mediated immunity. Cancer Immunotherapy- 
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 10
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 24

BMS PowerPoint Revised - AdoptiveCellTherapyfor...

This preview shows document pages 1 - 10. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online