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CELL SIGNALING - present in the cell Two types he mentioned...

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BILD 1:The Cell T A: Zara Tabi ([email protected]) Week 5 $n*o Cell Siqnalinq. cont. il-'rRRnsoucrtoru - Amplification of original signal \ \ Phosphorulation cascad*A series of protein activation Jbpggh \ nhnenhnnrlafinn' One nrntein aefivates another which activates 'gb_"Sphg.ylgt'g!:. one pr.oteil activates^anotl::Ylli:l ":1.",.11?:-,another, etc' ffiiiTiEa-?ri,proF-riate protein for the RESPONSE step is activated. The best way to understand this process is through a diagram: @t no {&me pneu le&fs..- - -'-h- _-----Y* f), rniial itqnrd bnds ft rr.ccltn( // PrDfih, artivuttnq fltr neYt propilr m (tv sqna! seffienu' Cus,raltq ffrroqh PhrlQhon{u'n on) -\ {@1 d'aa*rqtfdlftl'xroH \1 tuxt Protein rh ,'> 1C? trrroolr' P*osPnrrqtan /t t/ / \1 @ annl/ tu Prorrn r'dPnerbae @ ltr * %ff;:'" Second Messenqer Siqnalinq-- the initial reception activates an enzyme that produces or releases muttipte small molecules, which act as signals (known as secondary messengers) for other receptor proteins
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Unformatted text preview: present in the cell. Two types he mentioned in class:-cAMP (cyclic AMP)- Produced with a G-protein coupled receptor- rheJt$lgg:2ggn herps-Calcium ions (Ca++;- Ca++ usually kept in low concentrations in the cytoplasm- Kept in high concentrations outside the cell or in membrane compartments (ER, mitochondria, etc.) using proton pumps- Action potentials (change in the membrane voltage, such as the intake of positive ions) signals their release ) released Ca++ then acts as a signal molecule for other receptor proteins v @ Lvenwtlll, thr @ iotls enMtnq ftt ull c\r.lfiqe rhs 0 The inrrlal signal brnols fnQkinq ft 'iltuw to nn ioYt channel , allowtnX p(tflVe' \*t iovts h qo drtNn ft, (theff's an attrnctl'on tu Iw O gvtvtVonfhgnt inSrdr [lrr. ctlrt ) @ ir 's Tltis chaltSc ^ .+l_ f,uat rP'!eo&e,s ,llu Lo " I fows lylb fIt^l clbPu''uur Ca+' RESPONSE- Very specific, can be affected by a couple of factors (see slide 20, lec. 10) cq#...
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