Lecture10_2010 - BIO 320 CELL BIOLOGY Spring 2010 A. De...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO 320 - CELL BIOLOGY – Spring 2010 A. De Lozanne Lecture 10 - Nuclear Transport Reading: Alberts, 5th Ed. Pages 695-712 the following sections: The Compartmentalization of Cells All Eukaryotic cells  have the same basic set of… Evolutionary origins  explain the topological relationships of organelles. Proteins can move  between compartments in different ways Gated Transport Transmembrane Transport Vesicular Transport Signal Sequences  direct proteins to the correct cell address. Most organelles cannot be constructed de novo… Panel 12-1 Approaches to studying signal sequences The Transport of Molecules between Nucleus and Cytosol Nuclear pore complexes  perforate the nuclear envelope Nuclear localization signals  direct nuclear proteins to the nucleus Nuclear import receptors  bind nuclear localization signals… Nuclear export  works like nuclear import but in reverse. The Ran GTPase  drives directional transport… Transport between the nucleus and cytosol can be regulated… During mitosis  the nuclear envelope disassembles Outline I. General Aspects of Protein Sorting A. Proteins encoded by      nuclear genes  may have localization signals. B. The localization signal  is a specific peptide sequence within the sequence of the entire protein. C. In the absence  of a localization signal the protein will remain in the cytosol. D. The sequence of the localization signal is different for different compartments. E. Proteins can have more than one  localization signal. F. Protein sorting occurs by specific pathways G. Localization signals are recognized by specific protein receptors . H. Proteins with appropriate signals  are targeted for uptake into specific organelles I. Further sorting  can occur within a compartment to segregate proteins. I. The Structure and Function of the Nuclear Pore Complex A.  move in  1.     moved into nucleus across the nuclear envelope  1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/12/2010 for the course PSY 339 taught by Professor Neal during the Spring '09 term at University of Texas at Austin.

Page1 / 4

Lecture10_2010 - BIO 320 CELL BIOLOGY Spring 2010 A. De...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online