Lecture11_2010_notes - BIO 320 CELL BIOLOGY Summer 2009 A...

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BIO 320 - CELL BIOLOGY – Summer 2009 A. De Lozanne Lecture 10. Transport of Proteins into Mitochondria Reading: Alberts, 5th Ed. Pages 713-719 the following sections: The Transport of Proteins into Mitochondria  Translocatio n into the mitochondrial matrix depends on… Mitochondrial precursor proteins  are imported as unfolded… ATP hydrolysis  and a Membrane Potential drive Bacteria & Mitochondria  use similar mechanisms… Transport into the Inner Mitochondrial Membrane PLUS: The mitochondrion  contains an outer membrane, an …pp 816-817 The citric acid cycle  generates high-energy electrons As electrons move along the respiratory chain , …pp 820 The proton gradient  drives ATP synthesis , pp 821 The proton gradient  drives coupled transport ..., pp 822 Figures 14-14 and 14-15 OPTIONAL READING: 2 review articles posted on Blackboard K.L. Adams & J. D. Palmer (2003) Evolution of mitochondrial gene content: gene loss and transfer to  the nucleus Molec. Phylogenet. Evol. 29:380-395 K. Mihara (2003) Moving inside membranes.  Nature 424:505-506 Outline I. Mitochondria : Organization and Function. A.  Evidence that mitochondria originated by endosymbiosis: 1. Mitochondria have a size similar to that of bacteria . 2. Mitochondria have their own genome  that encodes their own ribosomal subunits,  tRNAs and some of the mitochondrial proteins . 3. The sequence of the mitochondrial genes is most similar to purple bacteria  than to related  genes of the host cell. 4. The inner membrane  has a lipid composition  similar to that of bacteria;  virtually devoid  of cholesterol and rich in cardiolipin.
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