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Lecture9.2010 - BIO 320 CELL BIOLOGY T O'Halloran A De...

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BIO 320 - CELL BIOLOGY Lecture 9 (02/16/2010). Endocytosis And Exocytosis Reading: Alberts, 5th Ed. Pages 799-809 Endocytosis :  Cellular Uptake of Particles and Macromolecules A. Phagocytosis  is the cellular uptake of particulate matter  from the environment. B. Endocytosis  is the cellular uptake of material dissolved or suspended in fluid. 1. Bulk-phase endocytosis  does not require binding to the surface membrane. 2. Receptor-mediated endocytosis (RME)  follows the specific binding of substances to  membrane receptors. a. Ligand-bound receptors  collect in specialized regions of the membrane forming coated   pits .  The sorting signal appears to be a key tryosine  in the cytoplasmic tail of receptors. b. Clathrin-coated regions  invaginate  into the cytoplasm, forming coated vesicles . c. Clathrin contains three chains that form a triskelion capable of changing from a flat 
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