Chapter_5signaling

Chapter_5signaling - Chapter 5 Chemical Messengers Chapter...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 5 Chemical Messengers Chapter Outline Mechanisms of Intercellular Communication Chemical Messengers Signal Transduction Mechanisms Membrane-Bound Receptor-Mediated Responses Long-Distance Communication via the Nervous and Endocrine Systems I. Mechanisms of Intercellular Communication Direct Communication Through Gap Junctions Indirect Communication Through Chemical Messengers Gap Junctions Channels formed between 2 cells that are close together Direct electrical and metabolic coupling Common in smooth and cardiac muscle Indirect Communication Through Chemical Messengers II. Chemical Messengers Functional Classification of Chemical Messengers Chemical Classification of Messengers Synthesis and Release of Chemical Messengers Transport of Messengers Functional Classification of Chemical Messengers Paracrines Autocrines Neurotransmitters Hormones Neurohormones Cytokines
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Paracrines Released by cell, moves to target cell by diffusion Paracrines- act on neighboring cells Examples of Paracrine -Histamine (released with tissue damage and causes dilation of local blood vessels) -Clotting Factors -Testosterone (Moves from Leydig cells into the seminniferous tubles) -Prostaglandins -Paracrine substances, act locally, very potent in small amounts, regulate cellular responses to hormones, can activate or inhibit adenylate cyclase (controls cAMP production and alters cells response to hormones), wide variety of functions Autocrines -Act on cells that release it Neurotransmitters Messengers of nervous system Released from neuron by exocytosis Diffuses to very close target cell across a synapse Hormones Messenger of endocrine system Released from endocrine gland Transported in blood to target Target cell = cells in body with receptors specific to the hormone Neurohormones -Hormones released from the axons of neurons in the hypothalamus ADH and Oxytocin in posterior pituitary Inhibiting and releasing hormones into the portal system going to the anterior pituitary Cytokines = peptides or proteins Can be transported in blood Released by most cell types Involved in cell development, differentiation and immune responses Often act on a wide range of targets
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/12/2010 for the course BIOL 2160 taught by Professor Kt during the Spring '08 term at LSU.

Page1 / 9

Chapter_5signaling - Chapter 5 Chemical Messengers Chapter...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online