IntroductionMeasuring instrumentation, as well as other analytical tools are of extreme importance in almost every industry in the world2. Precision and accuracy in measuring are critical to acquiring useful data for experiments, tests, projects, etc. Take the medical field for example, in preparation for a surgery, the anesthesiologist must take vital measurements of the patient, in order to prepare a crucially precise anesthesia, specific to that patient’s biochemical needs. A dosage too little in concentration puts the patient at risk of gaining consciousness during surgery, and a dosage too large may put the patient in a permanent state of sleep, comma or death. For this, and thousands of other situations in multiple disciplines, measuring and precise use of analytical instrumentation is of great importance. Weighing by difference is a useful technique when dealing with reagents that are vulnerable to absorption of moisture from the air, these types of chemicals are called hygroscopic reagents.1This technique minimizes absorption of water by the sample or container with the all the available chemical to be used. To weigh by difference, the sealed container containing the hygroscopic reagent is placed and weighed on an analytical scale. With care, samples of chemical are transferred to a receiver of choice, andbottle is capped and weighed again. The difference in weight of bottle with reagent is the mass of sample transferred to the receiver. In the present experiment, students got the chance to practice, get familiar, and work on making the most precise and accurate measurements using a burette, a 10 mL volumetric pipette and an analytical balance.Materials and ProcedureMeasuring the mass of a coin 1.Analytical balance was turned on and zeroed2.Weighing paper was placed on scaled and its weight was recorded to the nearest 0.1 mg3.