Chen's Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease

Chen's Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease

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Hindawi Publishing Corporation Cardiovascular Psychiatry and Neurology Volume 2009, Article ID 424728, 3 pages doi:10.1155/2009/424728 Hypothesis Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease Hu Chen Department of Psychiatry, Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL 60612, USA Correspondence should be addressed to Hu Chen, chen@psych.uic.edu Received 6 May 2009; Accepted 24 June 2009 Recommended by Hari Manev The exact nature of the comorbidity between cardiovascular disease (CVD) and major depressive disorder (MDD) is poorly understood. The proposed mechanisms include various biochemical and molecular pathways as well as health behaviors such as physical inactivity. One possible link between MDD and CVD is increased platelet activity and blood viscosity. Recently, it was discovered that platelets express functional subtype of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, for example, glutamate receptor 1 (GluR1). Here, I propose that this type of AMPA receptor could play a role in comorbid MDD and CVD, and antidepressants may interfere with platelet activation via direct or indirect e f ects on platelet GluR1 phosphorylation. Testing this hypothesis could provide a novel view on the pathobiological mechanisms of comorbid MDD and CVD. With respect to the recently discovered role of AMPA receptors in regulating platelet activation and thrombosis, it appears that the information about the putative e f ects of psychoactive AMPA-modifying drugs on platelet AMPA receptors would be critical in evaluating the putative e f ects of such drugs on CVD. Copyright © 2009 Hu Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1. Introduction Epidemiological studies have identiFed a high incidence of comorbidity between cardiovascular disease (CVD) and major depressive disorder (MDD). These studies note that patients with MDD are at greater risk of developing CVD [1]. ±urther, they prompted the American Heart Association to recommend routine screening for depression in patients with coronary heart disease, a recommendation that still needs to be fully implemented [2]. The exact nature of the MDD-CVD association is poorly understood. The proposed mechanisms of this link include various biological, that is, biochemical and molecular pathways as well as the hypoth- esis that the association between depressive symptoms and cardiovascular events could be driven by health behaviors, especially physical inactivity [3]. One prominently hypothesized link between MDD and
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Chen's Possible Role of Platelet GluR1 Receptors in Comorbid Depression and Cardiovascular Disease

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