Khawaja eet al's Depression and Coronary Heart Disease Review

Khawaja eet al's Depression and Coronary Heart Disease Review

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Psych i atry 2009 [VOLUME 6, NUMBER 1, JANUARY] 38 ABSTRACT We performed a comprehensive review of the literature to determine whether or not a relationship between depression and coronary artery disease exists. Our literature search supports the following: Depression and coronary artery disease have a bidirectional relationship, i.e., coronary artery disease can cause depression and depression is an independent risk factor for coronary artery disease and its complications; depression may contribute to sudden cardiac death and increase all causes of cardiac mortality; and depression contributes to unhealthy lifestyle and poor adherence to treatment. We review various pathophysiological links between depression and coronary artery disease and screening for depression in at-risk patients for coronary artery disease. We also discuss pharmacological treatments, their implications, and various behavioral treatments. INTRODUCTION Coronary artery disease (CAD) has emerged as the leading cause of death and disability in the United States. DEPRESSION AND CORONARY ARTERY DISEASE: The Association, Mechanisms, and Therapeutic Implications by IMRAN SHUJA KHAWAJA, MBBS; JOSEPH J. WESTERMEYER, MD, PhD; PRASHANT GAJWANI, MD; and ROBERT E. FEINSTEIN, MD Dr. Khawaja is from Department of Psychiatry, University of Minnesota/VA Medical Center, Minneapolis, Minnesota (currently doing a fellowship in sleep medicine at the Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota); Dr. Westermeyer is from the Department of Psychiatry, University of Minnesota/VA Medical Center, Minneapolis, Minnesota; Dr. Gajwani is from the Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio; and Dr. Feinstein is from the Department of Psychiatry, University of Colorado School of Medicine, Denver, Colorado. Psychiatry (Edgemont) 2009;6(1):38–51 FINANCIAL DISCLOSURES: Drs. Khawaja, Westermeyer, and Feinstein have no conflicts of interest relevant to this manuscript. Dr. Gajwani is a consultant or member of the speakers bureau for AstraZeneca, Forest Laboratories, Pfizer, and Cyberonics, and has received research grants from Cyberonics, Pfizer, and Bristol-Myers Squib. ADDRESS CORRESPONDENCE TO: Dr. Imran Khawaja, Center for Sleep Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905; E-mail: khimran@yahoo.com KEY WORDS: coronary artery disease, depression, antidepressant medications, SSRIs [REVIEW]
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
[VOLUME 6, NUMBER 1, JANUAR Y ] Psych i atry 2009 39 According to an estimate by the World Health Organization (WHO), by the year 2020, both CAD and depression will be the two major causes of disability-adjusted life years. 1
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/13/2010 for the course PSYCH 101 taught by Professor Gabbart during the Spring '08 term at Union College.

Page1 / 14

Khawaja eet al's Depression and Coronary Heart Disease Review

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online