Chapter 15 - Microbial Mechanisms of Pathogenicity Chapter...

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Microbial Mechanisms of Pathogenicity Chapter 15
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Pathogenicity - ability to cause disease Virulence - degree of pathogenicity Many properties that determine a microbe’s pathogenicity or virulence are unclear or unknown But, when a microbe overpowers the hosts defenses, disease results!
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Portals of Entry 1. Mucus Membranes 2. Skin 3. Parentarel
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1. Mucus Membranes A. Respiratory Tract microbes inhaled into mouth or nose in droplets of moisture or dust particles Easiest and most frequently traveled portal of entry
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Common Diseases contracted via the Respiratory Tract Common cold Flu Tuberculosis Whooping cough Pneumonia Measles Strep Throat Diphtheria
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Mucus Membranes B. Gastrointestinal Tract microbes gain entrance thru contaminated food & water most microbes that enter the G.I. Tract are destroyed by HCL & enzymes of stomach or bile & enzymes of small intestine
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Common diseases contracted via the G.I. Tract Salmonellosis Salmonella sp. Shigellosis Shigella sp. Cholera Vibrio cholorea Ulcers Helicobacter pylori Botulism Clostridium botulinum
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Fecal - Oral Diseases These pathogens enter the G.I. Tract at one end and exit at the other end. Spread by contaminated hands & fingers or Poor personal hygiene.
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Mucus Membranes of the Genitourinary System - STD’s Gonorrhea Neisseria gonorrhoeae Syphilis Treponema pallidum Chlamydia Chlamydia trachomatis HIV Herpes Simplex II
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Mucus Membranes D. Conjunctiva – mucus membranes that cover the eyeball and lines the eyelid Trachoma Chlamydia trachomatis
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2nd Portal of Entry: Skin Skin - the largest organ of the body. When unbroken is an effective barrier for most microorganisms. Some microbes can gain entrance thru openings in the skin: hair follicles and sweat glands
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3rd Portal of Entry: Parentarel Microorganisms are deposited into the tissues below the skin or mucus membranes Punctures injections bites scratches surgery splitting of skin due to swelling or dryness
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Just because a pathogen enters your body it does not mean it’s going to cause disease. pathogens -
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This note was uploaded on 04/13/2010 for the course BIO 3302 taught by Professor Dr.nasreenhaque during the Fall '09 term at CUNY City Tech.

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Chapter 15 - Microbial Mechanisms of Pathogenicity Chapter...

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