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Unformatted text preview: kg adult: Vd = 130 L Clearance = 36 L / hr Oral availability = 83% Therapeutic concentration = 5 mg/L 1. What iv loading dose should be administered? 2. What constant infusion rate is required to maintain the therapeutic concentration? 3. What is the predicted half-life of the drug in the child? Answers: The patient is half the weight of the average adult => Vd and clearance witll be ~ one half the given values. Drug is given i.v. => oral availability irrelevant: 1. Loading dose = Vd x Cp = 130L/2 x 5 mg/mL = 325 mg 2. Infusion rate = Cl x Cp = (36 L / hr)/2 x 5 mg/mL = 90 mg/hr 3. T1/2 = ln2 x Vd/Cl = 0.693 x 130 L / 36 L/hr = 2.5 hrs...
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This note was uploaded on 04/13/2010 for the course BIMM BIMM118 taught by Professor David during the Winter '09 term at UCSD.
- Winter '09