Problemset 2-1

Problemset 2-1 - Which of the drugs qualifies as a partial...

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Which of the drugs qualifies as a partial agonist? Drug C: even at the highest concentration, only a fraction of the maximal response can be achieved A patient appears in the emergency room with a history of ingesting vinegar at a party where marijuana was smoked. The pH of his urine was found to be 2.0. What effect would this pH have had on 11-nor delta9-THC carboxylic acid (THC- COOH), a weak acid metabolite of marijuana? A. the THC-COOH would be ionized B. the concentration of THC-COOH in urine would be decreased C. the concentration of THC-COOH in urine would be increased D. the excretion of THC-COOH would be facilitated E. none of the above B. the concentration of THC-COOH in urine would be decreased: Lowering the pH of the urine (increasing urine H ion concentration) would increase the percentage of THC that is unionized (e.g. THC-COO- + H+ -> THC- COOH). This will increase passive re-absorption of the drug (lack of “trapping” in the urine) across cell membranes in the kidney, and lower the amount that stays in the renal filtrate (urine).
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The full effect of digoxin in slowing the heart rate after a single i.v. dose may
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This note was uploaded on 04/13/2010 for the course BIMM BIMM118 taught by Professor David during the Winter '09 term at UCSD.

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Problemset 2-1 - Which of the drugs qualifies as a partial...

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