Problemset 3-1

Problemset 3-1 - symptoms: A. Furosemide B. Digitoxin C....

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1) Captopril blocks: A. angiotensin II receptors B. angiotensin II formation C. bradykinin receptors D. bradykinin formation E. alpha1 adrenergic receptors B) Captopril is an ACE (Angiotensin Converting Enzyme) inhibitor. Bradykinin is metabolized by ACE, therefore its levels would increase, not decrease. 2) Sodium nitroprusside: A. is used to lower blood pressure in a hypertensive emergency B. increases smooth muscle cAMP levels C. has a slow onset and long duration of action D. is given orally E. inhibits nitric oxide formation A) Nitroprusside is given i.v. to lower blood pressure. It has a rapid action and short half life and is therefore useful in titrating blood pressure to a desired level by altering its rate of infusion. 3) A patient arrives in the ER after attempting suicide by taking a precription drug overdose with the following symptoms: Tachycardia; widened pupils; dry, flushed skin; dry mouth Which of the drug(s) on his nightstand are likely to be responsible for these
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Unformatted text preview: symptoms: A. Furosemide B. Digitoxin C. Atenolol D. Atropin E. Captopril D) The symptoms are consistent with the actions a a muscarinic parasympatholytic drug 4) Would furosemide increase of decrease the effects of digoxin? Increase: Diuretics cause a loss of potassium, resulting in lower potassium concentrations. Potassium competes with digoxin for binding the the Na+/K+ antiporter system => reduced K+ means less competition => increased effect of digoxin. 5) A patient starts treatment with probenecid for his gout, however, his condition seems to worsen rather than improve. What is a likely cause for this problem? Uricosuric agents at sub therapeutic concentrations inhibit excretion as well as reabsorption of uric acid. At therapeutic levels, inhibition of reabsorption dominates over inhibition of excretion....
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