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Problemset 5

Problemset 5 - A Glitazones B ACE-inhibitors C...

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1) A hypertonic patient with diabetis receives tolbutamide for his diabetic condition. Which drug would be contraindicated to control his blood pressure: A. Nifedipine B. Prazosine C. Minoxidil D. Atenolol E. Clonidine C) Tolbutamide increases insulin secretion by blocking potassium channels and causing membrane depolarization. Minoxidil opens potassium channels, thus hyperpolarizing the membrane (prevent Ca influx => no smooth muscle cells contraction => vasodilation) 2) Castor oil effects the bioavailability of which of the following drugs after oral administration: A. Cardiac glycosides B. Beta-blockers C. Lansoprazole D. Yohimbine E. Furosemide A,B,C,D,E) As a strong laxative, castor oil will effect the absorption of virtually all drugs from the intestine by reducing the time available for absorption. 3) Many drugs accumulate in the liver, which ususally represents an undesired effects. Which of the following drug groups benefits from increased hepatic concentrations?
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Unformatted text preview: A. Glitazones B. ACE-inhibitors C. Benzodiazepines D. Statins E. Barbiturates D) Statins: by accumulating in the liver, these HMG-CoA-reductase inhibitors are localized to the major site of cholesterol synthesis, where they will have the strongest effect. 4) Your diabetic patient is also an exercise fanatic. After a particularly strenuous workout, his blood glucose levels become alarmingly high. Which of the following would reduce this effect of strenuous exercise on blood glucose levels? A. a beta-adrenergic antagonist B. a beta-adrenergic agonist C. an alpha-adrenergic antagonist D. an alpha-adrenergic agonist E. a glucocorticoid (A) Sympathetic stimulation can increase glycogenolysis in liver cells, an effect mediated by beta-adrennergic receptors (activated by fight or flight release of epinephrine). The best choice is therefore to give a beta blocker, such as propranolol....
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