7+Alzheimer++s+notes

7+Alzheimer++s+notes - Neuronal loss and memory Alois...

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Neuronal loss and memory
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Alois Alzheimer “One of the first disease symptoms of this 51-year-old woman was a rapidly increasing memory impairment; she could not find her way about her home…” One hundred years ago
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About half of those over __ have AD
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AD risk factors • Prevalence doubles with every decade of life after 60. • Risk is higher for relatives of affected individuals. • More common in women. • Head trauma • High cholesterol • Lack of mental stimulation
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Maximum 30 points 26 points AD Mini-Mental State Test
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Answer questions about date and location (10 points): • 'What is the day of the week?' • 'What year was last year?' • 'What building are we in?'
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Memory (1 point for each of 3 objects). People are asked to remember three words e.g. 'pen, ball, ring'. The three object names will be asked for later in the test.
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Ability to concentrate. One test, scoring a maximum of 5 points, requires the person to subtract 7 from 100 and continue. The answers are 93,86,79,72, 65.
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• Name objects such as a brush or a pen (1 point each). • Do a 3-step command - 3 points. • Repeat a sentence - 1 point. • Copy a figure or shape - 1 point. • Write a sentence - 1 point.
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Brain atrophy in AD
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__________ atrophy in AD
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Plaques and tangles in the Alzheimer’s brain
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Amyloid plaques and tangles
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• Originally thought to be due to a loss of the acetylcholine cholinergic system system. • The major drug used to treat
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This note was uploaded on 04/14/2010 for the course BIO SCI BIO N110 taught by Professor Leon,chance&parker during the Spring '09 term at UC Irvine.

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7+Alzheimer++s+notes - Neuronal loss and memory Alois...

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