What the ephrin - Stress Things stress increases: Cytokines...

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Stress Things stress increases: Cytokines (IL-6) Attract immune cells to injuries. • Stress, smoking, and high fat diets increase them, but decreases them from the wound site (causing impaired immune system). NPY Mediates weight gain. Blocking NPY blocks obesity. Rats fed high fat will only gain weight when stressed. Glucocorticoids Stress pituitary ACTH Adrenal cortex Glucocorticoids Removing prevents neuronal loss
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Stress Glucocoricoids Cortisol (increases with age as well Corticosterone Limit glucose transport to the brain and delivers it to muscles instead (causes cell death) Receptors are greatest in the hippocampus (consolidation/new learning)
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Stress Things like seizures or hypoxia increase the brains vulnerability to stress. Seizures Excitatory glutamate Stimulate NMDA Increases intracellular calcium Calcium activated proteases (eat up stuff) Cell death GLIA are supposed to take up extra glutamate but they need glucose to function Glucose is not able to be used because of the glucocorticoids
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Which of the following occur(s) with chronic stress? A. Increased glucose transport to the brain to enhance cognition B. Increased the amount of glucocorticoid receptors in the brain C. Increased responsiveness to increased excitatory amino acids D. Increased protease activity with increased extracellular calcium E. Two of the above
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Drugs that affect stress affect GABA Alcohol, barbiturates (phenobarbitol), benzodiazepines (xanax) Bind to GABA and induce more Cl- to be released. Hyperpolarizes the cell (inhibits it). Taking too many at once can cause death because of too much inhibition DBI (endogenous) Bind to the benzodiazepine site and BLOCKS GABA Increases anxiety Caffeine Also blocks GABA and increases excitement by blocking Cl- Allopregnanolone Steroid synthesized in the glia. Increases Cl- for more inhibition. Has its own binding site. YOUR BODY’S WAY OF CALMING YOU DOWN Stress
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through _________ receptors to change __________ ion flow, leading to hyperpolarization and inhibition of neurons. A. GABA; K+
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What the ephrin - Stress Things stress increases: Cytokines...

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