chance-04.24 - NEUROBIOLOGY & BEHAVIOR BIO SCI N110...

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NEUROBIOLOGY & BEHAVIOR BIO SCI N110 Spring Quarter 2009 April 24, 2009
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What is a receptive field? from book glossary: “region of receptor surface that causes a sensory nerve cell to respond”
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ganglion cell Stephen Kuffler in 1950’s recorded from ganglion cells and found that they respond to small circular patches of light Some ganglion cells respond to light turning on (ON-responses) and some to light turning off (OFF-responses) This is how one would measure the receptive field ” of a ganglion cell
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ganglion cell no action potentials are fired in this circuit before ganglion cells synapses are graded glutamate is release is directly related to V m (V m = membrane potential)
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ganglion cell primary path of information photoreceptor bipolar cell ganglion cell
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photoreceptor bipolar cell ganglion cell LIGHT t1 t0 t2
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photoreceptor bipolar cell ganglion cell LIGHT t1 t0 t2 pre-synaptic glutamate release decreases in presence of light increases when light turns off photoreceptor V m ADAPTATION
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Types of receptors involved in ON and OFF pathways of retina AMPA and kainate receptors Glutamate binds, channel pore opens, Na + ions flow into post-synaptic neuron glutamate -> post-synaptic depolarization “OFF PATHWAY”
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chance-04.24 - NEUROBIOLOGY & BEHAVIOR BIO SCI N110...

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