chance-05.06 - response of an olfactory receptor neuron to...

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NEUROBIOLOGY & BEHAVIOR BIO SCI N110 Spring Quarter 2009 May 6, 2009
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odor molecules
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olfactory receptor cells
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- immunoglobins “HELPER PROTEINS” = sustentacula cells
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“VOLTAGE CLAMP” (-) SIGN “INWARD CURRENT” POSITIVE CHARGE FLOWS INTO CELL Na+ ions entering cell Ca2+ ions Ca2+ ions leaving cell
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Odorant transduction: 1) odorant binds receptor, activates olfactory-specific G-protein 2) G olf activates adenyl cyclase III (olfactory-specific adenylate cyclase) 3) activation of adenyl cyclase III increases cAMP 4) cAMP-gated Na + and Ca 2+ channels open
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dorant transduction: cAMP-gated Na + and Ca 2+ channels open Influx of Na + and Ca 2+ ions activation of Ca 2+ -gated Cl - channels Efflux of Cl - ions Depolarization
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Ca2+ binds calmodulin Ca2+ - CAM Ca2+ - CAM decreases affinity of cAMP-gated channels for cAMP cAMP-gated channels close Ca2+ extruded Cl- - channels close
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Why have intracellular cascades? -- amplification of signals? 1. One odorant molecule Many cAMP – gated Channels to open 2. Ca2+ influx activates many Cl- channels More depolarization
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Unformatted text preview: response of an olfactory receptor neuron to isoamyl acetate (banana) Delay, Weak response Delay, Stronger response Faster response, Stronger response No odor Olfactory receptor tuning: 1) each olfactory receptor cell expresses one (or a few) olfactory receptors 2) chemical specificity/tuning of a receptor is hard to determine olfactory bulb glomeruli axons of olfactory receptor neurons contact mitral cells also connections from tufted cells and periglomerular cells tufted and periglomerular cells thought to sharpen or alter sensitivity/specificity each glomerulus is thought to respond to specific odorants How odor identity and odor concentration are mapped onto glomeruli responses is still unknown granule cells are an inhibitory network of neurons and have no axon (form dendro-dendritic synapses with mitral cells) function = lateral interactions? Lateral olfactory tract = mitral cell axons Primary target of The mitral cells...
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chance-05.06 - response of an olfactory receptor neuron to...

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