Parker+New+Exam+ANSWERS - 1. A membrane that is permeable...

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1. A membrane that is permeable to Cl- is separating two solutions. On the left is a 100mM solution of KCl and on the right is a 1000mM solution of NaCl. What is the membrane potential difference? 58mV 2. What is responsible for the hyperpolarization seen after an action potential? Slow closing of K channels 3. What are two examples of inward current that are seen in most normal human nerves? Na influx during the rising phase of an action potential and Ca influx that triggers neurotransmitter release 4. How could one generate an antidromic action potential? Use an electrode to stimulate the middle or end of the axon 5. When performing a voltage clamp on a squid giant axon, what range of voltages will result in Na+ efflux? Greater than about 58mV 6. If an axon is depolarized by an electrode to -10mV, the neuron will continue to depolarize up to 50mV. Why when the axon is voltage clamped to -10mV does the neuron not depolarize to 50mV? Voltage clamp holds cell membrane potential at a given voltage by injecting the current into the cell that directly opposes any ionic current. 7. Why is increasing axon diameter a less efficient way of increasing axon speed than myelination? Increasing axon diameter decreases resistance as a function of 1/(radius) 2 but it also increases capacitance as a function of (radius) 8. When horseradish peroxidase is added to a synapse that is subsequently fixed and examined, where can the horseradish peroxidase be found? What does this show? After enough time, horseradish peroxidase will be found in the vesicles being released, those being recycled and the endosome. This shows that vesicles are recycled (for small neurotransmitters at least). 9. For small neurotransmitters, what is produced in the cell body of the neuron? Enzymes 10. How can a cell change its conductance? Open or close channels 11. What is the definition of an ionotropic receptor? A receptor that has its ligand binding site and its channel on the same protein without a second messenger 12. What is the relationship between M.E.P.P.’s and E.P.P.’s EPP’s are made up of many (about 100) MEPP’s since MEPP’s represent 1 vesicle of
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This note was uploaded on 04/14/2010 for the course BIO SCI BIO N110 taught by Professor Leon,chance&parker during the Spring '09 term at UC Irvine.

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Parker+New+Exam+ANSWERS - 1. A membrane that is permeable...

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