N110Lecture02 - 45 I CHAPTER TWO Box A THE REMARKABLE GIANT...

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Unformatted text preview: 45 I CHAPTER TWO Box A THE REMARKABLE GIANT NERVE CELLS OF SQUID Many of the initial insights into how ion diameter—100 to 1000 times larger than able electrical measurements. The rela- concentration gradients and changes in mammalian axons. Squid axons are tive ease of this approach yielded the membrane permeability produce electri- large enough to allow experiments that first intracellular recordings of action cal signals came from experiments per- would be impossible on most other potentials from nerve cells and. as will formed on the extraordinarily large nerve cells. For example, it is not diffi- be discussed in the next chapter. the first nerve cells of the squid. The axons of cult to insert simple wire electrodes experimental measurements of the ionic these nerve cells can be up to 1 mm in inside these giant axons and make reli- currents that produce action potentials. in n 1: Giant axon Brain Presynaptic f Stella te __ (2nd level) nerve lst level neuron Smaller axons 2nd level neuron 3rd level neuron / ' f . u- |.- . .II. .' _ 1:. ._"I - _ ._f_":q'_ I . I _l _ 1 u . I . ;- I... H. r " "' I 1h r I . ""' ‘1'- " ' "'I a I E . I I rfi '\- 'n.= "' . "- {I n' I . . I- _ _ - _-. - . I 1-: .I u 1' -_ If . -' ' I _ i- T '32}: " I F P r - Ir . .' .' "'2. -‘ 1 :.'r. 05 m I 1.. .I I_'__ I' . _ ._ ._._-._'.'|.1| I.r * . _. -_ . a; - . . I‘m-l..- ' i 1- .. . u . -_11"1_Irrl.:flr “r I . .I . .- I" J. I‘d: In. ' - In} in I_f-c-r .-_ __._ - 1 F v .-_ , __ _ _. . r e e (A) + Mammalian axon = 2 um diameter (A) Diagram of a squid. showing the location of its giant nerve cells. The second-level neuron forms a series of fingerlike processes. each of Different colors indicate the neuronal components of the escape cir- which makes an extraordinarily large synapse with a single third-level cuitry. The first- and second-level neurons originate in the brain, while neuron. (C) Structure of a giant axon of a third-level neuron lying the third-level neurons are in the stellate ganglion and innervate mus- within its nerve. The difference in the diameters of a squid giant axon cle cells of the mantle. (B) Giant synapses within the stellate ganglion. and a mammalian axon are shown below. El eoEro cLeglca’ env;ronmanl' __________ m N‘ MM mV |n£'lJ9.. FQIALn;9 , [:0 autézdfl. K+ 2.0 4-00 - 75" Net" 44.0 50 + 55' C I _ 510 ~ :00 — 4.3 2+ 5 Ca IO O 000] + H;- 5’ Aclhml Potential JEPQHJ: upon (Calabhlc. PermeaL'IL'l'J 0" MGMLI’GQL '70 10““! ! :ofl mV DUr-II'IJ écE;on :6” "".'. +50 / Pl’meab'flflij ED Na... >> OEL‘J :45 ions, 50 Poktnkzq.‘ G'OJ‘, -§_ 0______ __ _______ 5° E»... 4 action E E L.’ _‘ b 3 "mega A m .. pum- ' - a J / k + >> oLch has" :9 E d _ . . l J E (av rut-43 PQLCQLN. O!"— ___9 V0 2, Nu": 2.2. across a. MEMLDC'GHQ. LO 5 .lven ;onf Gaialmqn fiuaéhpn Pk [klout 4’ Pu..[N6]ool- 4’ EnECDIA 5'8 I93 PtrmcaLiliLJ b. ekkn‘.“:£fi'/ “GEO. CI kt kt, N...’ LEG. Intraccuvia’ “3‘5..v.-IJ COHC-ChEM-l'uoar GL‘QQ-A skd’ou s )opfi— as 4 1 and: 5,0 :2“ *I Pa.rm¢¢LihLJ Lo 0,... 2° ' H- r ' L F, -w '0 fl‘.” 0. ¢ [001' Geom¢f .5 3-5 .g» .. Stanz‘39 «I: .‘5 V —so 1 k " 5 c .9 O :- : o 5,090.- '-‘-‘- 5'3 nV/ lnaJolJ n1 C'L‘"'3_¢' 1"“ k... Conunkakbn j i; I.” . grad-ant. (Lg. NUQ‘E 3 g“ . . '- chJ: in) \- ‘30 MC!“ bran Q; membrane. PolicaLI-a’ (MV) Nor ma.) BLIAcQNU'u/ [NJ] 1 O 0 4- .5 O A (0.3 Oncrak :03... depolaf.ltako;n ProPa‘s 0...! Q! actively Q'on’ G. flflfVl‘ 0/ mo 3.. la. :6. ll Stumvihbc-fl- h:c(oe|¢cEIOJ.-v current pvltfl— N (CCO'J drEO‘I’acE dchj ‘rbtf'Potcnkaut (undead-rank) ————-?, 9:30., C kar‘wb Of.- 5 E 1': f 0" ELQ. ao‘flon Police-5E :a.‘ A“; “9.590030! to ifl¢feashs Ole- .014 PO‘Q';‘:~: pv‘scs I.) Pe'PO'Of;;Gb :06 Cribrzé'eaflCL 6-0.! capuéz flifi‘, evoke! ‘cn’a _ PGI¢ILL o‘.’ eaten refPOn 5g! © mu... Mental: may!“ Mame want at a; 430:Lflr SfCQJ. A 3 OCL :06 POL CAL :O' EIQUC'f along an 03100 3'50): H'- I. Same. 3.02.0— _ 5P¢QJ ‘6' #ate InPoll'an Lecuuafl. : (a) It me: «u» P.l.-..l.-.‘.lr 3.5., ' Ladl- wardf L R;3;aj B‘IhSi. F.":n .PLax‘ ' w — ra'a‘" ""'"""'“"- F’Fc LG" .1: . “’N m " Muzak... 09m _ ' w: 4......” Luciana, ,. :gns;k;vg N... I “O Mele- clef“ .(.I&:na gu’l..k . I I 0 N03 enter: 9%" © E’E'“ k.’ 4°50." J’ov” 91:93:“ ; i - ' OPOR in r¢5fonfe ‘70 Jqolqr'a‘Lae :or. _ l ceII «pumay... J @ Em... a; v :...: 43,... cc" Laptrro'ar'nulf 3b 59'5" ECUOIJ k * 0103.735 0.00m '05 One :Q' . 2:10 ...
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This note was uploaded on 04/14/2010 for the course BIO SCI BIO N110 taught by Professor Leon,chance&parker during the Spring '09 term at UC Irvine.

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N110Lecture02 - 45 I CHAPTER TWO Box A THE REMARKABLE GIANT...

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