Chapter 26 Testbank - Chapter 26 RNA Metabolism Multiple...

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Chapter 26 RNA Metabolism Multiple Choice Questions 1. DNA-dependent synthesis of RNA Pages: 1022-1023 Difficulty: 2 Ans: B RNA polymerase: A) binds tightly to a region of DNA thousands of base pairs away from the DNA to be transcribed. B) can synthesize RNA chains de novo (without a primer). C) has a subunit called λ (lambda), which acts as a proofreading ribonuclease. D) separates DNA strands throughout a long region of DNA (up to thousands of base pairs), then copies one of them. E) synthesizes RNA chains in the 3 ' 5 ' direction. 2. DNA-dependent synthesis of RNA Pages: 1022-1024 Difficulty: 2 Ans: A Which of the following statements about E. coli RNA polymerase is false ? A) Core enzyme selectively binds promoter regions, but cannot initiate synthesis without a sigma factor. B) RNA polymerase holoenzyme has several subunits. C) RNA produced by this enzyme will be completely complementary to the DNA template. D) The enzyme adds nucleotides to the 3 ' end of the growing RNA chain. E) The enzyme cannot synthesize RNA in the absence of DNA. 3. DNA-dependent synthesis of RNA Pages: 1022-1025 Difficulty: 2 Ans: C Which of the following statements about E. coli RNA polymerase (core enzyme) is false ? A) In the absence of the σ subunit, core polymerase has little specificity for where initiation begins. B) The core enzyme contains several different subunits. C) The core enzyme has no polymerizing activity until the σ subunit is bound. D) The RNA chain grows in a 5 ' 3 ' direction. E) The RNA product is complementary to the DNA template. 4. DNA-dependent synthesis of RNA Page: 1024 Difficulty: 2 Ans: D RNA polymerase from E. coli (core enzyme alone) has all of the following properties except that it: A) can extend an RNA chain and initiate a new chain. B) is required for the synthesis of mRNA, rRNA, and tRNA in E. coli. C) produces an RNA polymer that begins with a 5 ' -triphosphate. D) recognizes specific start signals in DNA. E) requires all four ribonucleoside triphosphates and a DNA template.
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Chapter 26 RNA Metabolism 5. DNA-dependent synthesis of RNA Pages: 1024-1025 Difficulty: 2 Ans: B The sigma factor of E. coli RNA polymerase: A) associates with the promoter before binding to the core enzyme. B) combines with the core enzyme to confer specific binding to a promoter. C) is inseparable from the core enzyme. D) is required for termination of an RNA chain. E) will catalyze synthesis of RNA from both DNA template strands in the absence of the core enzyme. 6. DNA-dependent synthesis of RNA Pages: 1025-1029 Difficulty: 2 Ans: B After binding by E. coli RNA polymerase, the correct order of events for transcription initiation is: A) closed complex formation, open complex formation, promoter clearance, start of RNA synthesis. B)
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Chapter 26 Testbank - Chapter 26 RNA Metabolism Multiple...

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