Chapter 16 Testbank - Chapter 16 The Citric Acid Cycle...

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Chapter 16 The Citric Acid Cycle Multiple Choice Questions 1. Production of acetyl-CoA (activated acetate) Page: 617 Difficulty: 2 Which of the following is not true of the reaction catalyzed by the pyruvate dehydrogenase complex? A) Biotin participates in the decarboxylation. B) Both NAD + and a flavin nucleotide act as electron carriers. C) The reaction occurs in the mitochondrial matrix. D) The substrate is held by the lipoyl-lysine “swinging arm.” E) Two different cofactors containing —SH groups participate. 2. Production of acetyl-CoA (activated acetate) Page: 617 Difficulty: 2 Which of the below is not required for the oxidative decarboxylation of pyruvate to form acetyl-CoA? A) ATP B) CoA-SH C) FAD D) Lipoic acid E) NAD + 3. Production of acetyl-CoA (activated acetate) Page: 617 Difficulty: 2 Which combination of cofactors is involved in the conversion of pyruvate to acetyl-CoA? A) Biotin, FAD, and TPP B) Biotin, NAD + , and FAD C) NAD + , biotin, and TPP D) Pyridoxal phosphate, FAD, and lipoic acid E) TPP, lipoic acid, and NAD + 4. Production of acetyl-CoA (activated acetate) Page: 617 Difficulty: 2 Which of the following statements about the oxidative decarboxylation of pyruvate in aerobic conditions in animal cells is correct? A) One of the products of the reactions of the pyruvate dehydrogenase complex is a thioester of acetate. B) The methyl (—CH 3 ) group is eliminated as CO 2 . C) The process occurs in the cytosolic compartment of the cell. D) The pyruvate dehydrogenase complex uses all of the following as cofactors: NAD + , lipoic acid, pyridoxal phosphate (PLP), and FAD. E) The reaction is so important to energy production that pyruvate dehydrogenase operates at full speed under all conditions.
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Chapter 16 The Citric Acid Cycle 5. Production of acetyl-CoA (activated acetate) Page: 619 Difficulty: 3 Glucose labeled with 14 C in C-3 and C-4 is completely converted to acetyl-CoA via glycolysis and the pyruvate dehydrogenase complex. What percentage of the acetyl-CoA molecules formed will be labeled with 14 C, and in which position of the acetyl moiety will the 14 C label be found? A) 100% of the acetyl-CoA will be labeled at C-1 (carboxyl). B) 100% of the acetyl-CoA will be labeled at C-2. C) 50% of the acetyl-CoA will be labeled, all at C-2 (methyl). D) No label will be found in the acetyl-CoA molecules. E) Not enough information is given to answer this question. 6. Reactions of the citric acid cycle Page: 620 Difficulty: 3 Which of the following is not true of the citric acid cycle? A) All enzymes of the cycle are located in the cytoplasm, except succinate dehydrogenase, which is bound to the inner mitochondrial membrane. B) In the presence of malonate, one would expect succinate to accumulate. C) Oxaloacetate is used as a substrate but is not consumed in the cycle.
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This note was uploaded on 04/14/2010 for the course BHC 3023 taught by Professor Harmen during the Spring '10 term at University of South Florida.

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Chapter 16 Testbank - Chapter 16 The Citric Acid Cycle...

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