LS4 Lect_20

LS4 Lect_20 - Cancer CancerDeaths

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Cancer
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Cancer Deaths Es-mated number of new cancer cases and deaths in the United States in 1997.
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Cancer: A cell growth disorder resulting from an alteration in genes (mutations) that lead to deregulated (transformed) cell growth. CANCER IS A GENETIC DISEASE Transformed cell: A cell with impaired abilities to control its proliferation and tissue characteristics.
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Tumor cells are aneuploid (euploid=2N) - loss or gain of chromosome number Evidence that Cancer is a genetic disease: Tumor genes can be carried by viruses Carcinogens are mutagens (Ames Test) leukemia - X ray exposure Tumor cells carry chromosomal rearrangements skin cancer - UV irradiation lung cancer - tobacco smoke
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Karyotype of Cancerous Cells Tumor cells frequently show aneuploidy (i.e. highly aberrant chromosome compliments). Arrows indicate rearranged chromosomes.
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Evidence that Cancer is a genetic disease : Some tumors show hereditary susceptibility Retinoblastoma (Rb) Ataxia telangeictasia (AT) Bloom’s Syndrome (Blm) Colorectal cancer (APC) Breast/Ovarian Cancer (BRCA1)
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This note was uploaded on 04/15/2010 for the course LS LS 4 taught by Professor Ribaya during the Winter '07 term at UCLA.

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LS4 Lect_20 - Cancer CancerDeaths

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