F09BIBClec9

F09BIBClec9 - (Lewy) Taylor et al. Science 296:1991(02)...

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Fig. 4-29 Lehn
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Protein disulfide isomerase Peptide prolyl isomerase Chaperones
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• ‘Tail-to-tail’ heptamers • Cage for folding GroEL/GroES (Hsp60/Hsp10)
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Fig. 4-31 Lehn
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Amyloidoses Diseases where mutant forms of normally occurring proteins accumulate in tissues as AMYLOID (insoluble aggregates) 2 very different stable protein conformations Native form Amyloid form
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Taylor et al. Science 296:1991(02)
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Alzheimer’s Pick’s (tau) Prion Parkinson’s
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Unformatted text preview: (Lewy) Taylor et al. Science 296:1991(02) β-cross • Fibers: helical arrangement of β-strands perpendicular to the fiber axis • Protein fibrils rich in β-sheets, even though native state of the proteins may lack β-sheets • Large number of fibrils adopt β-cross conformation Taylor et al. Science 296:1991(0 Stanley Prusiner Nobel Prize 1997 PRIONS • Protein Structure and Function in the Immune System...
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This note was uploaded on 04/16/2010 for the course BIBC 100 taught by Professor Nehring during the Spring '07 term at UCSD.

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F09BIBClec9 - (Lewy) Taylor et al. Science 296:1991(02)...

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