LAB 2 - Michele Ahmadi: Systems Physiology Lab 2 Tues-...

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Michele Ahmadi: Systems Physiology Lab 2 Tues- 6:40-10:00, Jen Insulin Regulation of Blood Glucose I. Abstract Plasma glucose levels are closely regulated by a negative feedback mechanism of the pancreas’ beta-cells. Using the Glucose Tolerance Test on six subjects, we were able to chart the increase in plasma glucose levels in response to the ingestion of a glucose-rich solution. Immediately following this plasma glucose increase, a significant decrease in glucometer readings occurred. Insulin levels remained elevated, and plasma glucose levels continued to decrease until the completion of the experiment. We established a general renal threshold of 180 mg% glucose, which was breached by one subject. However, there still were no positive urine glucose readings, which maintained that no renal threshold was actually reached in-so-much that the concentration of blood glucose exceeded the threshold level for total reabsorption by the kidney. Inevitably all subjects were able to maintain homeostasis via insulin secretion, ruling out severe metabolic errors. II. Intro The regulation of blood glucose levels is a perfect example of a negative feedback mechanism. As seen in this lab, the human body has an exceptional ability to regulate blood glucose levels during fasting and feasting so that we may remain in a functional state of homeostasis. Glucose is a ubiquitous fuel for most of our body, and is the primary source of energy for our brains. The transportation of glucose across cellular membranes is indirectly assisted by insulin. A low or high rate of glucose- transportation can result in excess accumulation or depletion of blood glucose. Such insulin inefficiencies have been termed hyperglycemia and hypoglycemia, respectively. Diabetes (type I and type II) is also caused by malfunctioning insulin stores. In both types of diabetes, the afflicted will suffer from high blood glucose levels resulting in increase fatigue, irritability, blurry vision, excess thirst or polydypsia, and possibly glucosurea –excretion of glucose in the urine once renal threshold has been breached. Having such a crucial role in body regulation and function, it is important for one to test for possible metabolic disorders when faced with any symptoms of insulin complications. Damage to the Pancreases should be immediately addressed, as this is where insulin is secreted, in the islets of Langerhans (specifically the Beta-cells). In regards to the diagnoses of diabetes, several tests are preformed that monitor the body’s ability to respond to changes in blood glucose levels. One particular
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test, the Glucose Tolerance Test, assays the change in blood glucose levels following an excess ingestion of glucose. This lab allowed the class to use the glucose tolerance test to monitor the changes in blood
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This note was uploaded on 04/03/2008 for the course EX SCI 01:146:357 taught by Professor Merrill during the Spring '08 term at Rutgers.

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LAB 2 - Michele Ahmadi: Systems Physiology Lab 2 Tues-...

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