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103Lect3powerpoint

103Lect3powerpoint - Slides BIS 103 G L Y C O L Y S IS C o...

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Slides BIS 103 4/5/10 GLYCOLYSIS Co-factors/vitamins “High energy” compounds
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H CHO OH H HO OH H OH H CH 2 OH H CHO OH H HO OH H OH H CH 2 OPO 3 2- GLC-6-P GLC ATP ADP CH 2 OH O H HO OH H OH H CH 2 OPO 3 2- ATP ADP CH 2 OPO 3 2- O H HO OH H OH H CH 2 OPO 3 2- CH 2 OPO 3 2- O CH 2 OH H HC OH CH 2 OPO 3 2- + HPO 4 2- NAD + NADH H C OH CH 2 OPO 3 2- O OPO 3 2- ATP ADP H C OH CH 2 OPO 3 2- O - O H C OPO 3 2- CH 2 OH O - O C OPO 3 2- CH 2 O - O C O CH 3 O - O ATP ADP F-6-P DHAP G-3-P 1,3 bisPGA 3-PGA 2-PGA PEP PYR H 2 O 1 2 3 4 5 6 7 8 9 10 on a per glucose basis, from here multiple all by 2 H O OH H OH H OH CH 2 OH OH H O OH H OH H OH CH 2 OPO 3 2- OH ATP ADP 1 2 O 3 POH 2 C OH CH 2 OH H OH H H OH O O 3 POH 2 C OH CH 2 OPO 3 2- H OH H H OH O ATP ADP 3 Fischer projection-open chain Ring form O F-1,6-bisP + H + 1 2 3 4 5 6 1 2 3 4 5 6 1,6 2,5 3,4 Haworth projection Aerobic Glycolysis HB pg 11
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Glycolysis, step 1 Not physiologically reversible- note arrow H CHO OH H HO OH H OH H CH 2 OH H CHO OH H HO OH H OH H CH 2 OPO 3 2- GLC-6-P GLC ATP ADP 1 Kinase Hexokinase In mammalian liver- glucokinase HB pg 11
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Glycolysis, step 2 Intramolecular rearrangment called Isomerization reaction catalyzed by a enzyme called an Isomerase- phosphoglucoisomerase Keto aldo interconversion- ketolisomerase H CHO OH H HO OH H OH H CH 2 OPO 3 2- GLC-6-P CH 2 OH O H HO OH H OH H CH 2 OPO 3 2- F-6-P 2 Physiologically reversible Δ G o = +1.7 kJ/mol Δ G = -2.9 kJ/mol (RBC) HB pg 11
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Glycolysis, step 3 CH 2 OH O H HO OH H OH H CH 2 OPO 3 2- ATP ADP CH 2 OPO 3 2- O H HO OH H OH H CH 2 OPO 3 2- F-6-P 3 F-1,6-bisP 1 2 3 4 5 6 Kinase reaction Phosphofructokinase Not physiologically Reversible Δ G o = -14.2 kJ/mol HB pg 11
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Glycolysis, step 4 Aldol Cleavage Rxn- Fructosebisphosphate aldolase = aldolase Δ G o = +23.9 kJ/mol Δ G = -0.23 kJ/mol CH 2 OPO 3 2- O H HO OH H OH H CH 2 OPO 3 2- CH 2 OPO 3 2- O CH 2 OH H HC OH CH 2 OPO 3 2- + DHAP G-3-P 4 O F-1,6-bisP 1 2 3 4 5 6 1 2 3 4 5 6 DHAP = Dihydroxyacetone-phosphate G-3-P = Glyceraldehyde-3-phosphate HB pg 11
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C O R 1 C R 2 R 3 C O R 4 R 5 H C O R 1 C R 2 R 3 + C O R 5 R 4 C O R 1 C R 2 R 3 H Requirements for cleavage: C-OH must be ! to carbonyl carbon A. GLYCOLYSIS: ALDOL CLEAVAGE H H Biochemist use α , β to label carbons next to functional groups α β Functional group HB pg 12
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CH 2 OPO 3 2- O CH 2 OH H HC OH CH 2 OPO 3 2- + G-3-P 5 O 1 2 3 4 5 6 DHAP Glycolysis, step 5 Isomerization- Ketolisomerase!
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