VitaminCoenzymeRelationshipMT1 - only as fully oxidized...

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Spring 2009 BIS103 Vitamin and Co-enzyme Relationship Co-enzyme name and abbreviation Vitamin for humans B name Function Comments Deficiency Disease FOR MIDTERM 1 : Thiamine pyrophosphate, TPP Thiamine B1 Decarboxylation of alpha keto acids Dry Beriberi -weakness, nerve degeneration, loss of nerve transmission; Wet Beriberi -edema, enlarged heart, heart failure Flavin Adenine Dinucleotide, FAD Riboflavin B2 Oxidation/reduction (electron transfer) Can be found in 3 forms: FAD (fully oxidized), FADH (semi- reduced or semi-oxidized, FADH2 (fully reduced); almost always protein bound Ariboflavinosis Nicotinamide Dinucleotide (phosphate), NAD, (NADP) Niacin (nicotinic acid, nicotinamide) B3 Oxidation/reduction (electron transfer) Hydride transfer= 2 electrons, 1 proton, both at same time, found
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Unformatted text preview: only as fully oxidized NAD+, or fully reduced NADH. Protein-bound or releasable as free co-factor Pellagra (black tongue in dogs)- dermitits, dementia, decrease appetite and weight. Only dietary deficiency to be epidemic in US. Untreated maize deficient source- disease in 50-60 days! Coenzyme A CoASH/CoA, (also in Acyl Carrier Protein, ACP) Pantothenic Acid B5 An Acyl carrier Acetyl is a 2C acyl unit Deficiency rare, doesnt have specific name Lipoic Acid/lipoamide Not a vitamin- synthesized by humans Reductive acylation Typically covalently bound to enzyme N/A biotin Biotin B7 ATP-dependent carboxylations Typically covalently bound to enzyme Intestinal bacteria produce it, so dietary deficiencies are extremely rare- only if eat many raw eggs....
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This note was uploaded on 04/16/2010 for the course BIS 103 taught by Professor Abel during the Spring '08 term at UC Davis.

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