Lecture6powerpointslides

Lecture6powerpointslides - S lid e s T h u rs d a y A p ril...

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Slides Thursday April 15, 2010 Taxes due! • Misc TCA cycle – Reactions, uses REVIEW SESSIONS? Study Guide, Master Lists
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ALLOZYMES: Variant enzymes forms coded by different alleles at the same locus. Example from class: ALDH2 Glu and Lys enzymes are allozymes. ISOZYMES: Enzymes that perform the same function, but which are coded by genes at different loci. Example from class: ALDH1 and ALDH2 are isozymes.
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C O H 3 C SCoA CH 2 COO - CH 2 COO - HO COO - CH 2 COO - C CHCOO - COO - CH 2 COO - C H COO - COO - OH CH 2 COO - C H H COO - O CH 2 COO - C H H ScoA O + CO 2 COO - CH 2 CH 2 COO - GDP + Pi GTP + CoASH COO - C C - OOC H H C COO - C H HO H H COO - + H + ISOCITRATE ! -KETO- GLUTARATE SUCCINYL CoA C COO - H 2 C COO - O Acetyl CoA TCA CYCLE CITRATE cis-aconitate enzyme-bound OXALOACETATE FUMARATE SUCCINATE MALATE 1 2 3 4 5 6 7 8 CoASH + H + 2 NAD NADH CO 2 NAD NADH CoASH FADH 2 FAD H 2 O NAD NADH H 2 O H 2 O H 2 O H 1 H 2 C CH 2 COO - HO COO - C SCoA O NZ bound intermediate citryl CoA C o m m o n S y s t e m a t i c . 1. citrate synthase citrate OAA-lyase (acetyl CoA forming) 2. aconitase citrate hydro-lyase 3. isocitrate dehydrogenase isocitrate:NAD+ oxidoreductase(decarboxylating) 4. !
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