Serendipity, Magic, and Ritual 030310

Serendipity, Magic, and Ritual 030310 - 1 Horace Walpole...

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Unformatted text preview: 1 Horace Walpole 1754, The Three Princes of Serendip Serendipity is the "making discoveries by accident and sagacity, of things which one is not on quest of. Joseph Priestly, 1775 more is owing to what we call chance , that is, philosophically speaking, to the observation of events arising from unknown causes, than to any proper design, or preconceived theory in this business. Claude Bernard, 1865 "experimental ideas are often born by chance , with the help of some casual observations. Nothing is more common and this is really the simplest way of beginning a piece of scientific work. Robert Merton, 1958 the common experience of observing an unanticipated, anomalous and strategic datum which becomes the occasion for developing a new theory or for extending an existing theory. Dr. Jackie Corbin Dr. Sharron Francis Dr. Thomas Lincoln cGMP From 1989-1994: Pfizer Pharmaceutical began testing one new pharma compound called sildenafil 1 st phase clinical trial showed the relative safety, non-toxicity of drug and dosing 2 nd phase clinical trials used to test for efficacy of the drug on human patients with heart conditions Results 2 nd phase trials were a bit disappointing and perplexing. Found that sildenafil didnt really do much to increase blood flow to the heart in trial subjects However, unexpected, curious, and common side effects.penile erections When the first observations of erections were reported, the investigator who was doing the study in Wales was a little bit embarrassed to mention itwhen we explored the possibility of treating patients with erection problemssome of those patients said hey this is...
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Serendipity, Magic, and Ritual 030310 - 1 Horace Walpole...

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