13criticalperiod_2009

13criticalperiod_2009 - Ocular Dominance as a Model to...

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Ocular Dominance as a Model to Understand Mechanisms of Developmental Plasticity
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Eyelid suture is a model for conditions such as cataract, which can produce amblyopia (lazy eye or reduced vision through an eye).
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Transneuronal Labeling With Radioactive Amino Acids
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Autoradiograph of the visual cortex of a mature monkey that received a monocular injection of 3 H tritiated proline
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Lid suture at one week, at 11 months the deprived eye was injected with 3 H. A darkfield micrograph was taken, so that light patches correspond with labeled areas.
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Lid suture at four weeks, injected with 3 H proline in the normal (undeprived) eye; The dark (deprived eye columns are slim).
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Lid suture at seven weeks, label injected in the normal eye. Slight shrinkage of the unlabeled (dark) columns.
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At 8 weeks, the profile is the same as the adult. Thus the critical period is over by three months for a monkey (for the critical period last for years).
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Change Rapidly in Response to Monocular Deprivation
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13criticalperiod_2009 - Ocular Dominance as a Model to...

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