8-26-09 Genetic Methods in Neuroscience

8-26-09 Genetic Methods in Neuroscience - GeneticMethodsin...

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Genetic Methods in  Genetic Methods in  Neuroscience Neuroscience Dr. McKemy 8/26/2009
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Genetic Methods in Neuroscience Genetic Methods in Neuroscience Model systems Genetic approaches Knock-out animals Delete a specific gene of interest Knock-in animals Replace a specific gene of interest with an exogenous gene. Transgenic animals Insert a copy of an exogenous gene under control of the  regulatory elements of a specific gene of interest Tools Labeling select neurons Identifying neural networks Activating neurons within a network Inhibiting neurons within a network
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Model Organisms Model Organisms The nematode  Caenorhabditis elegans The fruitfly  Drosophila melanogaster The mouse  Mus musculus
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Number of genes in each organism. Model Organisms Model Organisms
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The nematode  The nematode  Caenorhabditis elegans Caenorhabditis elegans C. elegans have a very rapid life
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8-26-09 Genetic Methods in Neuroscience - GeneticMethodsin...

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