9-2-09 Ion Channels

9-2-09 Ion Channels - Ion Channels Ion Channels Dr. McKemy...

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Unformatted text preview: Ion Channels Ion Channels Dr. McKemy 9/08/2008 Use concentration and electrical gradients. Are usually selective for specific ions. ◦ K+, Na+, Ca2+, Cl-. Most are “gated” by specific signals. ◦ Chemical or electrical. Ion channels. Ion Types of voltage­gated ion channels Types of voltage­gated ion channels Types of ligand­gated ion channels Types of ligand­gated ion channels Measuring ion channel activity Measuring ion channel activity Measuring single Na+ channels Measuring single Na Measuring single K+ channels Measuring single K Na+ versus K+ channels Na Functional states of voltage­gated Na+ and K+ channels Functional states of voltage­gated Na Not all K+ channels are created equal Not all K K+ channels K+ channels Toxins That Poison Ion Channels Toxins That Poison Ion Channels • TTX from Puffer fish • Potent and specific for Na+ channels • Saitotoxin produced by dinoflagellates is a chemical homologue. • “Red tide” and shellfish. Tetrodotoxin­sensitivity of Na+ channel subtypes Tetrodotoxin­sensitivity of Na ...
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This note was uploaded on 04/18/2010 for the course BISC 421 at USC.

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