9-11-09 Synaptic Transmission II

9-11-09 Synaptic Transmission II - SynapticTransmissionII

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Synaptic Transmission II Synaptic Transmission II r. McKemy /11/2009
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Transporters Transporters Move ions or small molecules against their gradients. Require energy to move. “pumps” or moves solutes across the membrane. Electrochemical, concentration, or electrical potential. Critical for the creation of ion concentration gradients.
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Transport proteins Transport proteins
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Na Na + + /K /K + + -ATPase -ATPase Concentration of Na + is 10-20X greater out than in cells. Reverse for K + . Gradients are maintained by the plasma membrane Na + /K + -ATPase. Each cycle moves 3 Na + out and 2 K + in. Electrogenic : a net + charge across membrane. o Cell negative inside.
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Ion movements due to the Na Ion movements due to the Na + + /K /K + +  pump  pump
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Na Na + + /K /K + + -ATPase -ATPase Steps in ion movement cycle. 1. Na + and ATP binds to the intracellular side. 1. Increases ATPase activity. 2. Hydrolyses ATP to ADP. 1. The hydrolysis leads to phosphorylation. 1.
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This note was uploaded on 04/18/2010 for the course BISC 421 at USC.

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9-11-09 Synaptic Transmission II - SynapticTransmissionII

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