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9-14-09 Neurotransmitter Receptors

9-14-09 Neurotransmitter Receptors - Neurotransmitter...

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Neurotransmitter Neurotransmitter Receptors Receptors r. McKemy /14/2009
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A neurotransmitter can affect the activity of a postsynaptic A neurotransmitter can affect the activity of a postsynaptic cell via ionotropic and metabotropic receptors cell via ionotropic and metabotropic receptors
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Ligand-gated ion channels Ligand-gated ion channels Ligand-gated ion channels ionotropic receptors “fast” receptor (1 msec) Signal is intra - molecularly coupled. Opens ion channels to produce EPSPs and IPSPs
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Neurotransmitters can work through both receptor Neurotransmitters can work through both receptor types types Ionotropic Metabotropic
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The general architecture of ligand-gated receptors The general architecture of ligand-gated receptors
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The general architecture of ligand-gated receptors The general architecture of ligand-gated receptors
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The structure of the nACh receptor/channel The structure of the nACh receptor/channel Pentameric protein that has different subunit composition depending on where it is expressed.
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