9-16-09 Neurotransmitters, Synthesis, and Reuptake

9-16-09 Neurotransmitters, Synthesis, and Reuptake -...

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Neurotransmitters: Synthesis  Neurotransmitters: Synthesis  and Reuptake and Reuptake r. McKemy /16/2009
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Categories of neurotransmitters Categories of neurotransmitters
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Categories of neurotransmitters Categories of neurotransmitters
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Acetylcholine metabolism in cholinergic nerve  Acetylcholine metabolism in cholinergic nerve  terminals terminals Sarin (organophosphates) Neostigmine
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Myasthenia Gravis Myasthenia Gravis An autoimmune disease  that targets nicotinic Ach  receptors. Leads to reduced  numbers of nACh  receptors. Treatments with  cholinesterase  inhibitors.
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Glutamate and glutamate receptors Glutamate and glutamate receptors Glutamate is the major excitatory  neurotransmitter in the central nervous  system. Glutamate receptors are both  ionotropic and metabotropic. Ionotropic receptors. NMDA Signal integration Synaptic plasticity. Agonist is  N-methyl-D-aspartate Ampa Synaptic transmission. Synaptic plasticity. Agonist is  α -amino-3-hydroxyl-5-methyl- 4-isoxazole-proprionate. Kainate Synaptic transmission. Presynaptic modulation. Agonist is  kainic acid. Metabotropic receptors. mGluRs Have varied physiological functions. Both excitatory and inhibitory.
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NMDA vs AMPA glutamate receptors NMDA vs AMPA glutamate receptors Both use glutamate as the NT. Distinguished by their agonists NMDA or AMPA. Are functionally distinct due to a Mg 2+ block of the NMDA receptor at rest. AMPAs are not blocked by Mg
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This note was uploaded on 04/18/2010 for the course BISC 421 at USC.

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9-16-09 Neurotransmitters, Synthesis, and Reuptake -...

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