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9-18-09 Intracellular Signal Transduction

9-18-09 Intracellular Signal Transduction -...

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Intracellular Signal  Intracellular Signal  Transduction Transduction Dr. McKemy 9/18/09
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Amplification in signal transduction pathways Amplification in signal transduction pathways An important property of the activation of cell-surface receptors is the  amplification of the input signal. A single ligand-bound receptor can activate >100 G-proteins. Several hundred cAMP molecules. Down stream, the process can be further amplified.
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Categories of cellular receptors Categories of cellular receptors
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Receptor tyrosine kinases (RTK) Receptor tyrosine kinases (RTK) Membrane receptor proteins that are  involved in cell proliferation,  differentiation, and survival. Ligands include growth factors Nerve growth factor (NGF). Epidermal growth factor (EGF). Made up of three domains: An extracellular ligand binding domain.
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