2 pain_post

2 pain_post - receptors and terminology q temperature...

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receptors and terminology temperature » thermoreceptors » cool and warm pain » nociceptors » tissue damage » hot, cold, 1st pain (sharp, fast), 2nd pain (dull, slow)
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thermoreceptors are nonselective cation channels temperature receptors are members of the TRP family of channels both thermoreceptors and chemoreceptors
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nociceptors first pain via free nerve ending damage (potassium??) second pain via chemoreceptors
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nociceptors mast cell blood vessel p p p p histamine prostaglandins bradykinin initial damage releases peptides from vessels and mast cells that signal the pain peptides induce substance P release from neurons to promote feedforward signaling aspirin blocks prostaglandin synthesis
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hyperalgesia = sensitization sensitization is likely caused by spreading chemoreception
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peripheral nerve
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spinothalamic tract: overview
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spinothalamic: spinal cord X X first synapse is in the dorsal horn second-order neuron crosses in the ventral white commissure arms will come in inside of legs L E G A R M
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This note was uploaded on 04/18/2010 for the course BISC 421 taught by Professor Hirsch,liman,quick during the Fall '08 term at USC.

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2 pain_post - receptors and terminology q temperature...

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