Liman Lecture 4 for BISC 421_2009_ taste_POST

Liman Lecture 4 for BISC 421_2009_ taste_POST - Taste Taste...

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Taste
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Taste buds and the peripheral innervation of the tongue Five tastes (or more?) Sour: e.g. citric acid Salty: NaCl Sweet: Sucrose Bitter: e.g. quinine Umami: MSG
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Structure of the taste bud
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How are different tastes detected? Specific receptors detect the tastants – “sweet receptor” (discovered in last 10 years!) Specific subsets of cells respond to each class of tastants (“sweet cells,” “sour cells”)
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Sweet and umami receptors
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Receptor are expressed in subsets of cells
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Evidence: A sweet response from T1R2+T1R3 Red indicates responding cells
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T1R2/R3 KO abolishes sweet taste
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Cats cannot taste sweet
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T1R2 is not expressed by Cats Brand lab, PLoS GENETICS, July 2005
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Molecular organization of the taste bud Bitter cells express bitter receptors – T2Rs Sweet cells express sweet receptor – T1R2+T1R3 (heterodimer) Umami cells express sweet receptor – T1R2+T1R3 (heterodimer) Bitter Umami Sweet + T1R3
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Wrong! TRPM5 is
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This note was uploaded on 04/18/2010 for the course BISC 421 taught by Professor Hirsch,liman,quick during the Fall '08 term at USC.

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Liman Lecture 4 for BISC 421_2009_ taste_POST - Taste Taste...

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