Liman Lecture 5 for BISC 421 VNO transduction_2009_post2

Liman Lecture 5 for BISC 421 VNO transduction_2009_post2 -...

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Pheromones Chemicals released by an animals that elicit a stereotyped behavioral or endocrine response in another animal of the same species
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The Vomeronasal System: a major site of pheromone detection No cortical representation
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Vomeronasal organ mediate pheromone responses in mice Proposed functions: Individual recognition Gender identification Male aggression Female parental care Synchronization of oestrus Induction of puberty Pregnancy block
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Two types of VNO receptors 187 V1Rs 70 V2Rs
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Transduction pathway for pheromones
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TRPC2 ion channel is expressed in the VNO sensory microvilli T R P T R P 2 N C TRPC2
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TRPC2 knockout eliminates electrical response to pheromones Firing of VNO neurons in Heterozygote and TRPC2 KO mice Pink bar is pheromone
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Resident Intruder Assay for Pheromone Responses A male mouse (the intruder) is introduced into a cage with an established mouse (the resident).
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Liman Lecture 5 for BISC 421 VNO transduction_2009_post2 -...

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