Liman sleep slides_December corrections

Liman sleep slides_December corrections - SCN receives...

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molecular clocks Per (Cry, Clk and Bmal) are all transcription factors. Bmal and Clk stimulate expression of Per and Cry . As Per and Cry mRNA goes up, with a delay, protein levels go up. Per and Cry enter the nucleus and turn off their own expression. As Per and Cry proteins go down, they stop supressing expresion of their own mRNA and Clk and Bmal can exert positive influence. the entire cycle takes about 24 hours
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Light entrainment of circadian rhythms
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Unformatted text preview: SCN receives input from eye (specialized melanopsin cells) Sends projection by way of SCG to pineal gland, which releases melatonin--melanopsin may be useful in treating insomnia due to jet lag and in the elderly • Awake state- increased activity of Reticular activating system acetylcholine Tuberomammillary histamine orexin Locus coeruleus norepinephrine Raphe nucleus serotonergic...
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Liman sleep slides_December corrections - SCN receives...

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