Midterm1 - MIDTERM EXAM PINK BMED2803 Brani Vidakovic...

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MIDTERM EXAM PINK BMED2803 Brani Vidakovic Thursday, 10/04/2007. Name Problem 1 2 3 4 Total Score /25 /25 /25 /25 /100
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1. Duchenne Muscular Dystrophy Dataset. Duchenne Muscular Dystrophy , DMD, is a genetically transmitted disease, passed from a mother to her children. Affected female offspring usually suffer no apparent symptoms and may unknowingly carry the disease. Male offspring with the disease die at a young age. Not all cases of the disease come from an affected mother. A fraction, perhaps one third, of the cases arise spontaneously, to be genetically-transmitted by an affected female. This is the most widely held view at present. The incidence of DMD is about 1 in 10,000 male births. The population risk (prevalence) that a woman is a DMD carrier is about 3 in 10,000. Figure 1: Each son of a carrier has a 50% chance of having DMD and each daughter has a 50% chance of being a carrier. From the course page http://zoe.bme.gatech.edu/~bv20/bmed2803/ (Exams or Data) download data set dmd.dat , dmd.mat , or dmd.xls . This dataset is modified data from Percy et al (1981) 1 (entries containing missing data excluded). It contains 194 observations corresponding to blood samples collected in a project to develop a screening program for female relatives of boys with Duchenne Muscular Dystrophy (DMD). The program was implemented in Canada and its goal was to inform a woman of her chances of being a carrier
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This note was uploaded on 04/21/2008 for the course BME 2400 taught by Professor Vidakovic during the Spring '08 term at Georgia Institute of Technology.

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Midterm1 - MIDTERM EXAM PINK BMED2803 Brani Vidakovic...

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