Week 3, Lecture 3, Kerb Cycle

Week 3, Lecture 3, Kerb Cycle - B I O L O G Y 0 2 3...

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Unformatted text preview: B I O L O G Y 0 2 3 30-Dec-09 Gardiner 1 The Krebs Cycle B I O L O G Y 0 2 3 30-Dec-09 Gardiner 4 Transition Reaction Pyruvates carboxyl (COOH) group is removed and given off as carbon dioxide Remaining 2 carbon acetate transfers its electrons to NAD+ ----- NADH Coenzyme A attaches to acetate by an unstable bond making Acetyl CoA (very reactive) which enters the Krebs Cycle B I O L O G Y 0 2 3 30-Dec-09 Gardiner 5 Pyruvic acid transported into the mitochondria by a facilitated transport system The pyruvic dehydrogenase enzyme removes a CO 2 from pyruvic acid and produces NADH remember that 2 pyruvates are produced from each glucose the pyruvates are converted to 2 NADHs and 2 acetylCoAs in this reaction the first 2 of the 6 glucose carbons are oxidized to CO 2 Like Fig. 6.12 Krebs Cycle Some of the energy released by oxidation of carbon atoms is used to convert ADP to ATP (one molecule per cycle) Substrate level phosphorylation NAD+ ------ NADH (3 molecules/cycle) FAD+ ------ FADH 2 (one per cycle) Oxygen not directly involved in cycle B I O L O G Y 0 2 3 30-Dec-09 Gardiner...
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This note was uploaded on 04/18/2010 for the course BIOLOGY 1223 taught by Professor Gardiner/lajoie during the Fall '09 term at UWO.

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Week 3, Lecture 3, Kerb Cycle - B I O L O G Y 0 2 3...

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