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Unformatted text preview: Immunology Non-specific Responses Skin dry, acidic barrier secretions are acidic (pH 3 - 5) and contain antimicrobials (e.g. lysozymes) Mucus traps microbes and particles swept out by action of cilia Stomach acidity kills most intruders General neutrophils (mobile phagocytotic white blood cells) macrophages (stationary or mobile) (Fig 6.15) eosinophils (large parasites) natural killer cells (NK find infected/damaged cells) Injury - immediate response Damaged cells send out chemical distress signals- interferon warns nearby cells- histamines call for backup- inflammation in tissue improves access- increased blood flow brings repair/damage control units- phagocytes attracted to damaged area- neutrophils then macrophages and NK cells Prolonged infection calls for reinforcements- flood of Neutrophils (pus)- fever response (destroy foreign protein)- out of control (septic shock) Injury - immediate response Fig. 44.2 Injury - prolonged response Damaged cells send out chemical distress signals...
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- Fall '09