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lecture 6 - TA Andrew Nguyen office hours Change to 10-11am...

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1 TA Andrew Nguyen office hours: Change to 10-11am on Monday in the lobby of Price Center Theater Professor Zhang will have an office hour (5:30-6:30 PM) tomorrow (April 16) in Rm 2250 of Cancer Center building (on the right side of the elevator on the second floor)
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2 Nondisjunction and Uniparental Disomy Nondisjunction – failure of paired chromosomes to separate in anaphase of meiosis I, or failure of sister chromatids to disjoin at meiosis II. Nondisjuction in meiosis produces gametes with 22 or 24 chromosomes. After fertilization by a normal gamate, form a trisomic or monosomic zygote, which are generally lethal and the embryo will be aborted. Occasionally, one of the trisomy chromosomes is lost during the initial stage of embryo cell proliferation and development proceeds normally - trisomy rescue . When the two rescued chromosomes are from the same parent, it is called uniparental disomy (UPD). UPD is either heterodisomy (non-identical chromosome) or isodisomy (identical chromosome).
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3 Nondisjuction at meiosis I Nondisjuction at meiosis II A1 Trisomy
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