DAKL6-032210Mutation

DAKL6-032210Mutation - Mutation Cancer Sickle Cell Anemia...

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Unformatted text preview: Mutation! Cancer Sickle Cell Anemia Learning Objectives for Mutagenesis • Mutations are the source of genetic diversity, but usually have a negative impact on gene function. • Mutations can arise spontaneously , or by exposure to a mutagen • What are some types of Point mutations , and how do they arise? • Explain Insertions and Deletions, and some ways they are caused. How does genetic diversity arise? Mutations • Spontaneous • “naturally” (spontaneous, background rate) mistakes in DNA replication, etc • Mutagens • Alter a base (alkylation) • Replace a base (base analogs, intercalators) • Damage a base (UV crosslinking) Repair • Direct repair • Base Excision Repair • Nucleotide Excision Repair • Homologous Recombination • Non-homologous End Joining Luria and Delbruck experiments Lederberg experiments p. 518-519 Concept: Mutations can occur spontaneously Mutations occur before a selection event, not in response to it. Consequences of point mutations within genes Figure 15-2 Point mutations can alter mRNA splicing Transition = replacement of a base by the other base of the same chemical category. Transversion = replacement of a base of one chemical category by a base of the different category. Purine = Adenine and Guanine Pyrimidine = Thymine and Cytosine ATGCCCGAAGTG TACGGGCTTCAC Point Mutations (Base Substitutions) ATGCCC A AAGTG TACGGG T TTCAC ATGCCC T AAGTG TACGGG A TTCAC transition purine...
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This note was uploaded on 04/25/2010 for the course BIOL 202 taught by Professor Kieber-hogan during the Spring '08 term at UNC.

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DAKL6-032210Mutation - Mutation Cancer Sickle Cell Anemia...

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