DAKL6-032210Mutation

DAKL6-032210Mutation - Mutation! Cancer Sickle Cell Anemia...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Mutation! Cancer Sickle Cell Anemia Learning Objectives for Mutagenesis Mutations are the source of genetic diversity, but usually have a negative impact on gene function. Mutations can arise spontaneously , or by exposure to a mutagen What are some types of Point mutations , and how do they arise? Explain Insertions and Deletions, and some ways they are caused. How does genetic diversity arise? Mutations Spontaneous naturally (spontaneous, background rate) mistakes in DNA replication, etc Mutagens Alter a base (alkylation) Replace a base (base analogs, intercalators) Damage a base (UV crosslinking) Repair Direct repair Base Excision Repair Nucleotide Excision Repair Homologous Recombination Non-homologous End Joining Luria and Delbruck experiments Lederberg experiments p. 518-519 Concept: Mutations can occur spontaneously Mutations occur before a selection event, not in response to it. Consequences of point mutations within genes Figure 15-2 Point mutations can alter mRNA splicing Transition = replacement of a base by the other base of the same chemical category. Transversion = replacement of a base of one chemical category by a base of the different category. Purine = Adenine and Guanine Pyrimidine = Thymine and Cytosine ATGCCCGAAGTG TACGGGCTTCAC Point Mutations (Base Substitutions) ATGCCC A AAGTG TACGGG T TTCAC ATGCCC T AAGTG TACGGG A TTCAC transition purine...
View Full Document

Page1 / 30

DAKL6-032210Mutation - Mutation! Cancer Sickle Cell Anemia...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online