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DAKL8-032610Translation

DAKL8-032610Translation - Translation Inyourbody,...

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Translation
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In your body, information flows from DNA               RNA             Protein Replication DNA Polymerase Transcription Translation RNA Polymerase Ribosome Process in Black,  Enzyme in Blue Enzymes are proteins that catalyze  a specific biochemical reaction
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Learning Objectives for Translation Using the universal amino acid Codon table, be able to convert mRNA codons or original DNA sequence into amino acids Summarize how Ribosomes, tRNA , and mRNA all work together in protein synthesis - Take note of the big differences between Prokaryote and Eukaryote Translation Using your knowledge on transcription and translation, predict how DNA mutation can lead to synthesis of a non-functional protein
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Translate! Using the genetic chart below determine what mRNA codon represents methionine? A. ACU B. ATG C. AUG D. UGG First Base Second Base
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3’ GCT/GGA/GCA/GGC/AAG/ACA 5’  Normal sequence of CFTR DNA gene DNA Template Strand 18 bases = ? amino acids?  5’ CGA/CCT/CGT/CCG/TTC/TGT 3’
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DNA  RNA Amino  Acid First Base Second Base 3’ GCT/GGA/GCA/GGC/AAG/ACA 5’ mRNA=5’CGA/CCU/CGU/CCG/UUC/UGU3’ A.A.s = arg / pro / arg / pro / phe / cys
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Mutation #1 Change base 1 from G in DNA to an A in the DNA  CT GGA GCA GGC AAG  ACA  CT GGA GCA GGC AAG  ACA A G 3’ GCT/GGA/GCA/GGC/AAG/ACA 5’ Remember: Rare tautomeric forms of bases can form  mismatches.  A rare 5’ Imino form of C, could bind to A  during replication.
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DNA  RNA Amino  Acid First Base Second Base  3’  A CT GGA GCA GGC AAG  ACA mRNA=5’UGA/CCU/CGU/CCG/UUC/UGU3’ A.A.s = (nothing)
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How many amino acids long is your new protein from the given sequence? A. 6 B. >6 C. 0 D. 1 Possible Test Question:
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Mutation #2 Remove the nucleotides in the 13 th , 14 th , and 15 th position. Shift the rest of the pieces to close the gap 3’GCT GGA GCA GGC AAG ACA5’ GCT GGA GCA GGC ACA GCT GGA GCA GGC AAG ACA
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DNA  RNA Amino  Acid First Base Second Base 3’ GCT/GGA/GCA/GGC/ACA 5’ mRNA=5’CGA/CCU/CGU/CCG/UGU3’ A.A.s = arg / pro / arg / pro / cys
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