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Molecular Biology of the Cell

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Outline Types of regulation (general) Feedback inhibition Double-Reciprocal l Allosteric regulation l Covalent bonding of additional side chains
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Regulating Protein Activity 3 main categories of enzyme regulation 1. Feed back inhibition 2. Allosteric regulation 3. Covalent modification Phosphorylation/dephosphorylation
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Irreversible Inhibitors Permanently bound to enzyme Nerve gas- affect nervous system Some heavy metals Not really an option for the cell!!!
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Enzyme Inhibition Reversible means of regulation is more common Two ways inhibitors work competitive inhibition: binds with active site Competing with the substrate non-competitive inhibition: binds with sites other than active site
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Competitive inhibitor Resemble the substrate and competes with the substrate for active site binding (substrate analog) However it does not react or form the same bonds as the substrate. principle of many drugs Can better see and understand results if we use a different graph to show enzyme kinetics
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