Test 4 Notes - A simple Model for Signal Transduction in...

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A simple Model for Signal Transduction in Induced Resistance (MAPK)
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Outline Receptor Location Cell Surface / Extracellular (cell membrane) Intracellular (inside cell / not in mem.) A Types of Receptor (How they work) Ion channel G-Protein Enzyme linked A Types of Signals Paracrine Autocrine Endocrine Synaptic
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Cell Surface vs. Intracellular
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Cell Surface Receptors Type of signal Water soluble Neurotransmitters / signal proteins Requires receptors on cell surface A Receptors On cell surface Transduces signal from outside of cell to the inside of the cell. (signal transducer) Result is altered behavior of target cell Three general types of cell surface receptors
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Cell-Surface Receptors A. Ion-channel receptors Rapid synaptic signaling Binding of signal to channel causes it to open B. G-protein-linked receptor Indirectly regulates a separate protein in plasma membrane Ion channels or enzymes are activated as a result Requires a trimeric GTP binding protein (G-protein) Fig 15-15, MBOC4
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Cell-Surface Receptors Enzyme-linked receptors have a variety of structures Many enzyme-linked receptors are protein kinases, or are associated with protein kinases C. Enzyme-Linked receptors Direct or indirect enzyme activity Ligand binding site outside and enzymatic site is inside of the cell Variety of structures and types
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16_23_slowly_rapidly.jpg
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Cell Signaling – The Big Picture Studying cell signaling helps us to understand: How cells interact to form an entire organism from a fertilized egg Some of the problems causing cancer How to develop new drugs targeting specific signaling pathways Any many other questions…
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Cell Signaling – The Big Picture
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Signals Work In Combination To
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Acetylcholine Produces Different Responses In Different Cell Types
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Forms of Cellular Signaling Contact-dependent Membrane to membrane contact (short range) Remain bound to cell surface Immune response / Cell Development A Paracrine Immediate environment Local mediators secreted, act over short distance Autocrine A Synaptic Long range Nerve cells (neurons) Electrical impulses A Endocrine Long range Hormone carry signal Relatively slow process
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Contact Dependent
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More Signaling Signaling between animal Signaling between plant Signaling between plants and animals
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Paracrine Signals Local mediators secreted, act over short distance Embryonic development: neighboring cells make identical developmental decision
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Nitric Oxide (NO) : Some cells synthesize nitric oxide NO synthase A NO small, hydrophobic Passes through cell membranes -internal receptors A NO diffuses into target cell, binds receptor (inside of cell), causes physiological change
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Nitric Oxide (NO) Paracrine Signaling Molecule
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Autocrine Signaling Autocrine signaling Specific kind of paracrine signaling Cell secretes signals that bind to its own receptors, or to receptors on identical neighboring cells Groups of Identical cells
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Autocrine signaling
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This note was uploaded on 04/20/2010 for the course BIOL 4064 taught by Professor Dr.reyna during the Spring '09 term at Ouachita Baptist.

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Test 4 Notes - A simple Model for Signal Transduction in...

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