lec15_16cytoskeleton_motorproteins

lec15_16cytoskeleton_motorproteins - Cytoskeleton...

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Cytoskeleton Cytoskeleton serves as internal skeleton that maintains cell shape and assists in movement of its parts. Elements of the cytoskeleton include: Actin Filaments Pseudopods Intermediate Filaments Microtubules
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Fig 16-1, MBOC 4 Cytoskeleton Stained With Coomassie Blue
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Cell Structure and Function Loewy, 1991 Fig 2-38
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Cytoskeleton & Changes in Cell Shape Elements can rapidly assemble and disassemble Others are more stable Allows cells to build a wide range of structures
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Actin filaments are 5-9 nm in diameter Sometimes called Microfilaments Microtubules (MT) are 25 nm in diameter Intermediate filaments (IF) are ~10 nm in diameter
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Intermediate Filaments Assembly: 8–11 nm in diameter, between actin filaments and microtubules in size Most stable portion of cytoskeleton and most heterogeneous Components vary with cell type and state of differentiation. Structure is two coiled coils
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Intermediate Filaments Intermediate filaments are made up of subunits that form extended α-helical rod- like domains Monomers dimer Two dimers antiparallel tetramer With 8 bundles making up a fiber.
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Function of Intermediate filaments
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Functions of Intermediate filaments Strength and support Withstand mechanical stress/ Very stable
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Intermediate Filaments In Nerve Cells
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Nuclear Lamina
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Microtubules (MT) A. Made of hollow tube with polarity - Subunits of tubulin (globular proteins) MT grow differently at ends Assembled from dimers of alpha and beta tubulin has two ends (-) end (+) end (+) end grows faster than (-) end Dynamic instability – rapidly assemble / disassemble
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A. Tubulin & Microtubule Structure
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B. Role in Cell (general) help maintain shape of cells and acting as tracks along which organelles move. Polarizes cell Mitotic spindle fibers. /segregate chromosomes cilia and flagella
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Centrosome (Animal Cells) Regulation of MT assembly is under control of a MT organizing center (MTOC): called a centrosome . Centriole – cylindrical array of MT found in center of centrosome
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Regulation of MT all cells have Microtubule Organization Center (MTOC) but not all are organized by centrioles some centrosomes have no centrioles some centrosomes organize MTs in cilia, called basal bodies not same as flagella in bacteria plants and have centrosomes without centrioles
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Finds Center Of Cell
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lec15_16cytoskeleton_motorproteins - Cytoskeleton...

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